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INVESTIGATIONS BIOCHIMIQUES, HISTOLOGIQUES ET HISTOENZYMOLOGIQUES
SUR L'EFFET HEPATOPROTECTEUR DES FRACTIONS METAL-PROTEINES A
FAIBLE POIDS MOLECULAIRE, ISOLLES DE MYTILUS GALLOPROVINCIALIS LMK.


Maria Mirza 1), A. Abraham 2)
1) Institute Roumain de Recherches Marines Constanta
2) Centre de Recherches Biologiques Cluj-Napoca

Abstract
Metal binding proteins with a low molecular weight, isolated from 
Mytilus galloprovincialis(whole body) presented a moderate protecteur
effect upon liver of white Wistar rat intoxified with carbon tetra-
chloride (CCl4), comparative with Sylimarine - Biofarm drug action.
In lots of normal, intoxified-treated rats had been determined by
hystological and hystochemical methods: total lipids, L-lactat NAD+
- oxydoreductase (E.C.1.1.1.27), succinat dehydrogenase (E.C.1.3.99),
ferrocytochrom: oxygen oxydoreductase (E.C.1.9.3.1), ATP - phospho-
hydrolase (Mg dep.) (E.C.3.6.1.3); orthophosphomonoester phospho-
hydrolase (E.C.3.1.3.2). Observations on relative weight modifica-
tions and macroscopic aspects for liver, spleen, thymus gland,
adrenal glands was effected. In blood serum was assayed cholesterol,
FLL (free leucine like) of serum, L aspartat: 2 oxoglutarat amino-
trasnferase (E.C.2.6.11), L alanin: 2 oxoglutarat aminotrasnferase 
(E.C.2.6.1.2), unspecific cholinestherase (E.C.3.1.1.8), orthophos-
phomonoesther phosphohydrolase (E.C.3.1.3.1). The moderate hepato-
protector effect of Mytilus extract was observed by reduction of
hepatomegalia, returns of normal liver aspects and in some case
returns on the studied parameters (serum cholinestherase).