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COMPOSITION EN ELEMENTS CHIMIQUES ET EFFETS PHARMACOLOGIQUES
DES FRACTIONS METAL-PROTEINES A FAIBLE POIDS MOLECULIRE
ISOLLES DE MYTILUS GALLOPROVINCIALIS LMK.


Maria Mirza 1), Raluca Galani 2) et Maria Salagean 3)

1) Institute Roumain de Recherches Marines Constanta
2) Institut de Controle d'Etat du Medicament et de Recherches
   Pharmaceituque Bucarest
3) Institut de Physique Atomique Bucarest


Abstract
The isolation and purification method for low molecular-weight metal-
binding proteins from Mytilus galloprovincialis by means of fracti-
onated precipitation with acetone and dialyzation was presented. By
instrumental neutron activitation analysis was determined 19 
elements: As, Au, Ba, Br, Ca, Co, Cr, Fe, Hg, La, Na, Ni, Rb, Sb, Sc,
Se, Sm, Zn, W and by chemical assay N2 and P. The concentrations of 
elements and hepatoprotector effect fluctuated seasonaly with maximum 
values in spawning, in spring and autumn. By gas cromatography was 
identified in the metal-protein fractions 20 aminoacids, in which 
methionine represented about 20%. Pharmacological tests evidenced a 
detoxifying and hepatoprotector effects of these low molecular 
fractions upon liver of white Wistar rat intoxified with allyl 
alcohol.