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COMPOSITION CHIMIQUE ET ACTIVITE ANTIINFLAMATOIRE, ESSENTIELLEMENT
ANTIHYALURONIDASIQUE, DU PRODUIT ALFLUTOP R - SOLUTION INJECTABLE,
MEDICAMENT ORIGINAL ROUMAIN OBTENU D'ORGANISMES MARINS


Natalia Rosoiu

Institute Roumain de Recherches Marines Constanta

Abstract
The Romanian original  drug ALFLUTOP R - the injectable solution, 
prevents  the dizorganization of the normally constituted macro-
molecular structures and stimulates the tissue and periarticular
restitution in inflamatory affections located at the level of the
interstitial and periarticular tissues, including the articular
cartilage; it influences favourably the Ca ion dynamics in the
components with plastic and supporting role. The term of antihyalu-
ronidase is used for indicating the inhibitory effect on the 
enzymatic activity of hydrolysis of the mucopolysaccharide called
hyaluronic acid. The hyaluronic acid is distributed in the fun-
damental substance of the conjunctive tissue and achieves a role
of tissular bond, working as an intercellular "cement". In the
degenerative rheumatic arthropathies, the hyaluronic acid is
intensively depolymerizated by the hyaluronidase. So, the anti-
inflamatory effect of our original drug consists in inhibating this
enzyme which becomes "inapt" to depolymerizate the hyaluronic acid.
On the other hand, in the presence of the enzyme and an assembly
of specifical chemical compounds: free amino acids, sugars (glycogen,
hexoses, glucuronate), cations with very important role (Na, K, Ca,
Mg, Fe, Cu and Zn) etc., the biosynthesis of the hyaluronic acid 
takes place "in vivo" from its components. These two phenomena lead
to a common final point, the antiinflmatory and tissue restitutive
effects, also initiating other enzymatic processes of restitution
(for example cartilaginouses).