p. 201 - 215 

THE STUDY OF THE SULPHOMUCOPOLYSACCHARIDES OUT
OF MYTILUS GALLOPROVINCIALIS (LMK) 

A.I. Molnar, E. Tucicov, N. Boesteanu, Y. Cristescu 
The Institute of Chemical Pharmaceutical Researches, Bucharest 
Maria Mirza 
The Romanian Marine Researches Institute Constantza

Abstract
The content and the properties of the sulphomucopolysaccharides
(MPS) from Mytilus galloprovincialis have been studied. Out of 1 kg
dry tissue 5.9 g of partially purified mucopolysaccharide were 
obtained, having 3.71% N, 1.37% S, 2.25% hexuronic acid, 11.7% 
humidity and 9.3% residum on calcination.
The study of the toluidine blue colouring function of the MPS 
concentration in the sample firstly the moving of the extinction
maximum from 620 to 585 nm, then, on bigger MPS concentrations to
625 nm. From a pharmaceutical point of view, the anticoagulant 
activity in comparison with the heparine is insignificant. The
preparation shows an intense antilipidic and anticholesterolemic
activity on rat, against the tritonic hyperlipidemy. A protective
effect against the increase of the optical density of the serum,
against hyperlipidemy and hypercholesterolemy determined by 
Triton A 20 are noticed. The colouring properties with toluidine-
blue, the very small anticoagulant action and the protective 
effect in experimented hyperlipidemy and hypercholesterolemy
situate the MPS from Mytilus galloprovincialis in the same group
with the mucopolysaccharides from the digestive tractum of cattle
pork and fowl.